Ok, I have Windows Vista and this is the first time I've noticed this happen. When I right click the desktop and it takes me to appearence and personalization, it'll have a list of things I can click on, which are:
Window Color and Appearence
Desktop Background
Screen Saver
Sounds
Mouse Pointers
Theme
Display Settings

Everytime I click on one of these (except for Desktop Background, an error message will come up saying "Windows cannot find 'C:\Windows\System32\rundll32.exe'. Make sure you typed the name correctly, and then try again." And programs, folders, documents don't want to open sometimes.

How do I fix this? I'm not typing in anything, just clicking. Thanks in advance.
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Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 4:02:51 AM, on 5/3/2008
Platform: Windows Vista (WinNT 6.00.1904)
MSIE: Internet Explorer v7.00 (7.00.6000.16643)
Boot mode: Normal

Running processes:
C:\Windows\system32\Dwm.exe
C:\Windows\Explorer.EXE
C:\Windows\system32\taskeng.exe
C:\Program Files\Windows Defender\MSASCui.exe
C:\hp\support\hpsysdrv.exe
C:\Program Files\Hewlett-Packard\On-Screen OSD Indicator\OSD.exe
C:\Program Files\Intel\Intel Matrix Storage Manager\IAAnotif.exe
C:\Windows\RtHDVCpl.exe
C:\Program Files\HP\HP Software Update\hpwuSchd2.exe
C:\Program Files\Nero\Nero 7\InCD\NBHGui.exe
C:\Program Files\Nero\Nero 7\InCD\InCD.exe
C:\Program Files\Windows Sidebar\sidebar.exe
C:\Program Files\Hewlett-Packard\HP Advisor\HPAdvisor.exe
C:\Program Files\Spybot - Search & Destroy\TeaTimer.exe
C:\Program Files\Google\Google Updater\GoogleUpdater.exe
C:\Windows\system32\schtasks.exe
C:\hp\kbd\kbd.exe
C:\Program Files\SUPERAntiSpyware\SUPERAntiSpyware.exe
C:\Program Files\Internet Explorer\ieuser.exe
C:\Program Files\Internet Explorer\iexplore.exe
C:\Windows\system32\SearchFilterHost.exe
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://ie.redirect.hp.com/svs/rdr?TYPE=3&a...&pf=desktop
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://ie.redirect.hp.com/svs/rdr?TYPE=3&a...&pf=desktop
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant =
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch =
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
O1 - Hosts: ::1 localhost
O2 - BHO: (no name) - {02478D38-C3F9-4efb-9B51-7695ECA05670} - (no file)
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Common Files\Adobe\Acrobat\ActiveX\AcroIEHelper.dll
O2 - BHO: Spybot-S&D IE Protection - {53707962-6F74-2D53-2644-206D7942484F} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O2 - BHO: Yahoo! IE Services Button - {5BAB4B5B-68BC-4B02-94D6-2FC0DE4A7897} - C:\Program Files\Yahoo!\Common\yiesrvc.dll
O2 - BHO: SSVHelper Class - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre1.6.0_01\bin\ssv.dll
O2 - BHO: Google Toolbar Helper - {AA58ED58-01DD-4d91-8333-CF10577473F7} - c:\program files\google\googletoolbar1.dll
O2 - BHO: Google Toolbar Notifier BHO - {AF69DE43-7D58-4638-B6FA-CE66B5AD205D} - C:\Program Files\Google\GoogleToolbarNotifier\2.1.1119.1736\swg.dll
O3 - Toolbar: &Google - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - c:\program files\google\googletoolbar1.dll
O3 - Toolbar: jBrowse Toolbar - {9E5BD40E-6287-11D6-9772-0002A5DD2483} - C:\PROGRA~1\jBrowse\JBO.dll
O4 - HKLM\..\Run: [Windows Defender] %ProgramFiles%\Windows Defender\MSASCui.exe -hide
O4 - HKLM\..\Run: [hpsysdrv] c:\hp\support\hpsysdrv.exe
O4 - HKLM\..\Run: [KBD] C:\HP\KBD\KbdStub.EXE
O4 - HKLM\..\Run: [OsdMaestro] "C:\Program Files\Hewlett-Packard\On-Screen OSD Indicator\OSD.exe"
O4 - HKLM\..\Run: [IAAnotif] "C:\Program Files\Intel\Intel Matrix Storage Manager\Iaanotif.exe"
O4 - HKLM\..\Run: [NvSvc] RUNDLL32.EXE C:\Windows\system32\nvsvc.dll,nvsvcStart
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE C:\Windows\system32\NvCpl.dll,NvStartup
O4 - HKLM\..\Run: [NvMediaCenter] RUNDLL32.EXE C:\Windows\system32\NvMcTray.dll,NvTaskbarInit
O4 - HKLM\..\Run: [RtHDVCpl] RtHDVCpl.exe
O4 - HKLM\..\Run: [CCUTRAYICON] FactoryMode
O4 - HKLM\..\Run: [HP Health Check Scheduler] c:\Program Files\Hewlett-Packard\HP Health Check\HPHC_Scheduler.exe
O4 - HKLM\..\Run: [SunJavaUpdateReg] "C:\Windows\system32\jureg.exe"
O4 - HKLM\..\Run: [HP Software Update] c:\Program Files\HP\HP Software Update\HPWuSchd2.exe
O4 - HKLM\..\Run: [NeroFilterCheck] C:\Program Files\Common Files\Ahead\Lib\NeroCheck.exe
O4 - HKLM\..\Run: [SecurDisc] C:\Program Files\Nero\Nero 7\InCD\NBHGui.exe
O4 - HKLM\..\Run: [InCD] C:\Program Files\Nero\Nero 7\InCD\InCD.exe
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\QTTask.exe" -atboottime
O4 - HKLM\..\Run: [Adobe Reader Speed Launcher] "C:\Program Files\Adobe\Reader 8.0\Reader\Reader_sl.exe"
O4 - HKLM\..\Run: [COMODO Firewall Pro] "C:\Program Files\COMODO\Firewall\cfp.exe" -h
O4 - HKLM\..\Run: [Malwarebytes Anti-Malware Reboot] "C:\Program Files\Malwarebytes' Anti-Malware\mbam.exe" /runcleanupscript
O4 - HKLM\..\RunOnce: [Launcher] %WINDIR%\SMINST\launcher.exe
O4 - HKCU\..\Run: [Sidebar] C:\Program Files\Windows Sidebar\sidebar.exe /autoRun
O4 - HKCU\..\Run: [WindowsWelcomeCenter] rundll32.exe oobefldr.dll,ShowWelcomeCenter
O4 - HKCU\..\Run: [HPAdvisor] C:\Program Files\Hewlett-Packard\HP Advisor\HPAdvisor.exe autoRun
O4 - HKCU\..\Run: [SpybotSD TeaTimer] C:\Program Files\Spybot - Search & Destroy\TeaTimer.exe
O4 - HKCU\..\Run: [swg] C:\Program Files\Google\GoogleToolbarNotifier\GoogleToolbarNotifier.exe
O4 - HKUS\S-1-5-19\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-19\..\Run: [WindowsWelcomeCenter] rundll32.exe oobefldr.dll,ShowWelcomeCenter (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-20\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User 'NETWORK SERVICE')
O4 - Global Startup: Google Updater.lnk = C:\Program Files\Google\Google Updater\GoogleUpdater.exe
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0_01\bin\ssv.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0_01\bin\ssv.dll
O9 - Extra button: Yahoo! Services - {5BAB4B5B-68BC-4B02-94D6-2FC0DE4A7897} - C:\Program Files\Yahoo!\Common\yiesrvc.dll
O9 - Extra button: (no name) - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O9 - Extra 'Tools' menuitem: Spybot - Search & Destroy Configuration - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O13 - Gopher Prefix:
O16 - DPF: {30528230-99f7-4bb4-88d8-fa1d4f56a2ab} (Installation Support) - C:\Program Files\Yahoo!\Common\Yinsthelper.dll
O20 - AppInit_DLLs: C:\Windows\system32\guard32.dll
O20 - Winlogon Notify: !SASWinLogon - C:\Program Files\SUPERAntiSpyware\SASWINLO.dll
O23 - Service: Ad-Aware 2007 Service (aawservice) - Lavasoft AB - C:\Program Files\Lavasoft\Ad-Aware 2007\aawservice.exe
O23 - Service: Intel® Alert Service (AlertService) - Intel® Corporation - C:\Program Files\Intel\IntelDH\CCU\AlertService.exe
O23 - Service: Apple Mobile Device - Apple, Inc. - C:\Program Files\Common Files\Apple\Mobile Device Support\bin\AppleMobileDeviceService.exe
O23 - Service: COMODO Firewall Pro Helper Service (cmdAgent) - COMODO - C:\Program Files\COMODO\Firewall\cmdagent.exe
O23 - Service: DQLWinService - Unknown owner - C:\Program Files\Common Files\Intel\IntelDH\NMS\AdpPlugins\DQLWinService.exe
O23 - Service: Google Updater Service (gusvc) - Google - C:\Program Files\Google\Common\Google Updater\GoogleUpdaterService.exe
O23 - Service: HP Health Check Service - Hewlett-Packard - c:\Program Files\Hewlett-Packard\HP Health Check\hphc_service.exe
O23 - Service: Intel® Matrix Storage Event Monitor (IAANTMON) - Intel Corporation - C:\Program Files\Intel\Intel Matrix Storage Manager\Iaantmon.exe
O23 - Service: InstallDriver Table Manager (IDriverT) - Macrovision Corporation - c:\Program Files\Common Files\InstallShield\Driver\1050\Intel 32\IDriverT.exe
O23 - Service: InCD Helper (InCDsrv) - Nero AG - C:\Program Files\Nero\Nero 7\InCD\InCDsrv.exe
O23 - Service: Intel DH Service (IntelDHSvcConf) - Intel® Corporation - C:\Program Files\Intel\IntelDH\Intel Media Server\Tools\IntelDHSvcConf.exe
O23 - Service: Intel® Software Services Manager (ISSM) - Intel® Corporation - C:\Program Files\Intel\IntelDH\Intel Media Server\Media Server\bin\ISSM.exe
O23 - Service: LightScribeService Direct Disc Labeling Service (LightScribeService) - Hewlett-Packard Company - c:\Program Files\Common Files\LightScribe\LSSrvc.exe
O23 - Service: Intel® Viiv™ Media Server (M1 Server) - Unknown owner - C:\Program Files\Intel\IntelDH\Intel Media Server\Media Server\bin\mediaserver.exe
O23 - Service: Intel® Application Tracker (MCLServiceATL) - Intel® Corporation - C:\Program Files\Intel\IntelDH\Intel Media Server\Shells\MCLServiceATL.exe
O23 - Service: NBService - Nero AG - C:\Program Files\Nero\Nero 7\Nero BackItUp\NBService.exe
O23 - Service: NMIndexingService - Nero AG - C:\Program Files\Common Files\Ahead\Lib\NMIndexingService.exe
O23 - Service: Intel® Remoting Service (Remote UI Service) - Intel® Corporation - C:\Program Files\Intel\IntelDH\Intel Media Server\Shells\Remote UI Service.exe
O23 - Service: SBSD Security Center Service (SBSDWSCService) - Safer Networking Ltd. - C:\Program Files\Spybot - Search & Destroy\SDWinSec.exe
O23 - Service: stllssvr - MicroVision Development, Inc. - c:\Program Files\Common Files\SureThing Shared\stllssvr.exe
O23 - Service: Viewpoint Manager Service - Viewpoint Corporation - C:\Program Files\Viewpoint\Common\ViewpointService.exe
O23 - Service: XAudioService - Conexant Systems, Inc. - C:\Windows\system32\DRIVERS\xaudio.exe

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End of file - 9707 bytes

Duplicate topic here.

Topic closed.