This problem usually occur when I read/write(download) files to one of my secondary hard drive (300gb, 127gb free).
Usually the mouse movement will shatter (not smooth, stop and go) before the cursor go dead, while I read/write to that specific hard drive, and cpu running 100%.
The problem will fix itself after I restart the computer.
If i just surf web/email/office work on the desktop, mouse will work fine for days. just when I access that hard drive, the mouse problem occur.
Could it be virus? worms? or things like that.