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Outlook 20023 Exchange 2003

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I am getting these errors back on 2 of my 60 users in exachange. All clients are using Outlook 2002. Have restarted the mail server but no help. Anyone know what I can do?

Your message did not reach some or all of the intended recipients.
Sent: 9/8/2006 3:11 PM

The following recipient(s) could not be reached:
'destination@theirdomain.com' on 9/8/2006 3:11 PM
The e-mail address could not be found. Perhaps the recipient moved to a different e-mail organization, or there was a mistake in the address. Check the address and try again.
<servername.mydomain.com #5.1.8 smtp;553 5.1.8 user@mydomain.com... Domain of sender address user@mydomain.com does not exist>

A couple things. This happens to multiple senders, all are verified as good addresses by other people emailing them. The users at my domain are definitely there and enabled. They can send email internal to the company network, but not to outside domains?

I am kinda desperate, any help would be great.

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