Now for my thinking behind the suggestion: For a video editing PC, you need two things - Horsepower (CPU) and HDD space/speed. Because running a RAID 0 will allow for more space and speed, it looks like this would be a good way to go.
So my suggestion (and thinking) is primarily based on whether this ZBrush program (and what you do with it) could be classified as "video editing". From your descriptions, it sounds like it could be.
Also, what you usually do in a "video editing build" is run the OS and applications of a single hard drive, and then have your RAID 0 drives separate, for use on the videos and editing. This way, if one drive fails, hopefully you won't lose everything And for complete redundancy of your OS drive, you could run it in a RAID 1.