Yes, shut down the programs, you should see their icons in the system tray (bottom right hand corner of your desktop next to the clock), right click on them and choose Exit, or Quit etc.
Then disconnect your computer from the internet and run Combofix. When it has completed, if it did not reboot your machine, reboot manually and reconnect to the internet. Post me the log that will be found at C:\Combofix.txt in your next reply.