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spybot search&destroy

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I have Spybot Search &Destroy loaded on my computer running on Vista Operating System and from time to time I get popups notifying me that there are changes being made to the Registry and giving me the option to accept or deny the changes. This always confuses me to say the least as I am not sure how to respond. What I find is if I opt to deny the change it just keeps on reappearing whereas if I accept the change it seems to permanently clear.
Any advice please?
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Neil Jones

Neil Jones

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Not without knowing what's actually changing, no. More details needed please.
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