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WIRELESS MOUSE AND Key Board not working

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I have recently bought a new computer (tower).
I Installed Windows XP with service pack 3, I Initially had problems with my wireless keyboard and mouse. Once I had changed the Bios and fixed problems with the USB ports I found they worked.
This lasted for 3 weeks, and then I booted up one morning & found they would not work.
My mouse and keyboard I have had for 3 years plus. (Worked well on previous computer with recently installed new version of XP as above)
My new mother board is a Gigabyte S-Series GA-MA69VM-S2
With a AMD Athlon X2 CPU
Microsoft Wireless Optical Mouse 2.0A
Microsoft Wireless Comfort Keyboard 1.0A
I tried as system restore to a date when they worked X.
I looked in device manager, no problems, all working well X.
Re checked the Bios all ok, USB key board enabled X
Reinstalled drivers for Intelipoint Mouse and Key board X.
Checked my mouse, keyboard, and receiver are working well on my laptop. Yes the laptop detected them and installed drivers within 2 min, they all worked well.
I tried using different USB ports front and back.X
When I unplug and replug the USB receiver on my new computer I some times gets a speech box (from bottom right of screen) saying “A problem occurred installing new hardware. This device may not work correctly”
At 46 I see myself lucky to have a full head of hair, this may not last long as this problem is making me pull it out. If anyone has some advice that would help, I would be eternally grateful.
Thanks Gary.
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Sorry guys if I have posted this in the wrong space. My reasoning is that i have heard SP 3 has some conflicts. I have no details and thougt sme one might be able to help.
Thanks Gary
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try uninstalling the drivers again...reboot with the hardware connected...windows will "find" the "new" hardware and install the drivers for it/them...may ask for cd with the drivers on it so have it handy..
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