Prior to this problem, I had a reliability rating of 10 (in the reliability monitor) for months. There have been no hardware or driver changes recently. The only software changes in the last week have been set up of OpenDNS and FireFox (with NoScript.) It boots into Safe Mode with Networking just fine.
Computer Specs are:
Asus A8N-E Motherboard
AMD X2 4600+ (S939) - Factory clocked...no overclocking
Antec TruePower II power supply (330W I believe)
4GB of RAM (4x 1GB Corsair XMS PC3200)
nVidia 7600GT (don't remember the brand)
2x 74GB Raptor
Any ideas? Should I just start troubleshooting the startup since it boots into safe mode?