It is always something to the like of "There is no disk in drive. Please insert a disk into \Device\Harddisk3\DR5"
The hard disk number changes, as well as the DR number. I just press 'cancel' until I'm prompted no longer and the programs start up.
Also, the programs in question are: Spybot S&D, SUPERAntiSpyware, Zune, PC Tools Antivirus