I did try swapping out the RAM as well as trying to boot from my secondary HD, but to no avail. My other thought is maybe the processor is overheating? The fans are all running -- the proc, video card, and case fans all OK. I haven't installed anything in a long time, so I don't think its software / virus related. Also, the problem has been coming in for a while. When I would have the computer on for longer than 20 mins, it would lockup -- CTRL-ALT-DEL did noting. Desktop would show everything, but keyboard and mouse wouldn't provide any input.
What to try next?
system specs: Asus P5GD2 mobo, 4gb crucial DDR2, winXP, P4 3.0ghz