I searched the forums for a similar situation and I did find :
So just out of curiosity we went and looked at her boot.ini file to find that it looked normal. There was no second line showing another OS in the file. So the solution for that user will not work for us I am afraid.
When trying to do the old fashioned right click delete we run into errors saying files on that drive are in use or are write protected. Her computer boots from the C drive and the drive causing the problem is the E drive. We just need it for extra space, not to store important system information on. I'm not sure if there is any easy way to fix this or not but any help would be greatly appreciated.
Important Info : Computer would boot fine and run fine before the second hard drive was installed so I would assume those files that are being "used" or are write protected are not necessary for the computer to function properly.
Thanks again for your help and I will provide as much information as possible.