I was recommended this site after posting my problem on Nortons forums. Please find a copy of my original post on that forum and some of the replies here.
I am about to attempt to troubleshoot what I believe is malicious activity on the HDD in question using another computer on my home network.
Firstly, my only way back from this once the system I enable the infected HDD on becomes infected itself, is a windows rollback (very least), reflash BIOS (most likely fix I have had to use before when it first infected this system I am using right now which has a new HDD in it)
Considering how nasty I believe this one to be...should I only attempt to run these scans on the drive/system from a different user account on my other computer system? (whilst my network is not controlled by a network server OS as such, I have a similarly named and passworded windows account on both computers)