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MAPI spooler problems, Cannot delete e-mail in OL

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When I open Outlook, it is slow to get going. A message is stuck in my outbox, and the error message "MAPI spooler has already begun transmitting this message" appears when I attempt to delete it or move it. There is an attachment to the message - a very large file.

Soon after opening Outlook my CPU climbs to 100% usage and stays there. I have to reboot to get the computer working properly.

Previously, I was also receiving the error message "To help protect your computer, Microsoft has closed the following program: Generic Host Process for Win32" - I stopped this error message following tips in a post on this site.

I have tried operating in Safe Mode to delete the Email in Outlook, however this error message occurs when attempting to delete the e-mail, move to another folder, or open any other folder in Outlook after the delete attempt:

"Unable to expand (delete, move) the folder. The set of folders could not be opened. The message file C:\Documents and Settings\(name)\Localsettings\Application\Data\Microsoft\Outlook\mailbox.pst can no longer be accessed because it has been damaged by another application."

My boss recommended that I set the system back to an earlier date, as if it hasn't been operating for the past few weeks or so. How would I go about doing this, and do you recommend this action at this point? (It is her laptop and she needs it fixed).
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