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Update your AntiVirus Software - It is imperitive that you update your Antivirus software at least once a week (Even more if you wish). If you do not update your antivirus software then it will not be able to catch any of the new variants that may come out.
Use a Firewall - I can not stress how important it is that you use a Firewall on your computer. Without a firewall your computer is succeptible to being hacked and taken over. I am very serious about this and see it happen almost every day with my clients. Simply using a Firewall in its default configuration can lower your risk greatly.
For a tutorial on Firewalls and a listing of some available ones see the link below:
Visit Microsoft's Windows Update Site Frequently - It is important that you visit http://www.windowsupdate.com regularly. This will ensure your computer always has the latest security updates available installed on your computer. If there are new updates to install, install them immediately, reboot your computer, and revisit the site until there are no more critical updates.
Install Spybot - Search and Destroy - Install and download Spybot - Search and Destroy with its TeaTimer option. This will provide realtime spyware & Hijacker protection on your computer alongside your virus protection. You should also scan your computer with this program on a regular basis just as you would an antivirus software.
A tutorial on installing & using this product can be found here: