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Help to rid [bleep] Pop-ups please

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My sister has a load of naughty ladies popping up on her home PC and it's driving her mad. She suspects her son of "growing up" I believe, but wants rid of them and can't seem to do so. I know so little about computers that I've asked her to do a Hijack This log and send it to me. I have copied this below. Before she sent it, she cleaned the computer with Ad-aware, Spybot etc.

Any help would be greatly appreciated.

Logfile of HijackThis v1.99.1
Scan saved at 12:51:49, on 31/10/2005
Platform: Windows XP SP2 (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 SP2 (6.00.2900.2180)

Running processes:
c:\Program Files\Common Files\Microsoft Shared\VS7Debug\mdm.exe
C:\Program Files\Java\j2re1.4.2_03\bin\jusched.exe
C:\Program Files\ATI Technologies\ATI Control Panel\atiptaxx.exe
C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkUFind.exe
C:\Program Files\Hewlett-Packard\HP Software Update\HPWuSchd.exe
C:\Program Files\Hewlett-Packard\Digital Imaging\bin\hpotdd01.exe
C:\Program Files\Messenger\msmsgs.exe
C:\Program Files\McAfee.com\VSO\mcmnhdlr.exe
c:\program files\mcafee.com\shared\mghtml.exe
C:\Program Files\MSN Messenger\msnmsgr.exe
C:\Program Files\WinZip\WINZIP32.EXE
C:\Documents and Settings\Deb\Desktop\downloads\hijackthis\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http://www.gophersearch.com/
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://www.gophersearch.com/
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.gophersearch.com/
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.msn.co.uk/
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant = http://www.gophersearch.com/
O2 - BHO: DownloadRedirect Class - {00000000-6CB0-410C-8C3D-8FA8D2011D0A} - C:\Program Files\iMesh\iMesh5\iMeshBHO.dll
O2 - BHO: AcroIEHlprObj Class - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 7.0\ActiveX\AcroIEHelper.dll
O2 - BHO: iMeshBar BHO - {5345A7A1-805A-4923-B505-86B2FEBA3FE0} - C:\Program Files\iMeshBar\bar\1.bin\IMESHBAR.DLL
O2 - BHO: (no name) - {53707962-6F74-2D53-2644-206D7942484F} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O2 - BHO: (no name) - {549B5CA7-4A86-11D7-A4DF-000874180BB3} - (no file)
O2 - BHO: (no name) - {FDD3B846-8D59-4ffb-8758-209B6AD74ACC} - (no file)
O3 - Toolbar: McAfee VirusScan - {BA52B914-B692-46c4-B683-905236F6F655} - c:\progra~1\mcafee.com\vso\mcvsshl.dll
O3 - Toolbar: iMeshBar - {5345A7A9-805A-4923-B505-86B2FEBA3FE0} - C:\Program Files\iMeshBar\bar\1.bin\IMESHBAR.DLL
O4 - HKLM\..\Run: [SunJavaUpdateSched] C:\Program Files\Java\j2re1.4.2_03\bin\jusched.exe
O4 - HKLM\..\Run: [ATIPTA] C:\Program Files\ATI Technologies\ATI Control Panel\atiptaxx.exe
O4 - HKLM\..\Run: [Microsoft Works Update Detection] C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkUFind.exe
O4 - HKLM\..\Run: [HP Software Update] C:\Program Files\Hewlett-Packard\HP Software Update\HPWuSchd.exe
O4 - HKLM\..\Run: [HPDJ Taskbar Utility] C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb08.exe
O4 - HKLM\..\Run: [DeviceDiscovery] C:\Program Files\Hewlett-Packard\Digital Imaging\bin\hpotdd01.exe
O4 - HKLM\..\Run: [VSOCheckTask] "c:\PROGRA~1\mcafee.com\vso\mcmnhdlr.exe" /checktask
O4 - HKLM\..\Run: [VirusScan Online] "c:\PROGRA~1\mcafee.com\vso\mcvsshld.exe"
O4 - HKLM\..\Run: [MCAgentExe] c:\PROGRA~1\mcafee.com\agent\mcagent.exe
O4 - HKLM\..\Run: [MCUpdateExe] C:\PROGRA~1\mcafee.com\agent\mcupdate.exe
O4 - HKLM\..\Run: [MSKAGENTEXE] C:\PROGRA~1\McAfee\SPAMKI~1\MSKAgent.exe
O4 - HKLM\..\Run: [MSKDetectorExe] C:\PROGRA~1\McAfee\SPAMKI~1\MskDetct.exe /startup
O4 - HKCU\..\Run: [ctfmon.exe] C:\WINDOWS\system32\ctfmon.exe
O4 - HKCU\..\Run: [MsnMsgr] "C:\Program Files\MSN Messenger\MsnMsgr.Exe" /background
O4 - HKCU\..\Run: [MSKAGENTEXE] C:\PROGRA~1\McAfee\SPAMKI~1\MSKAgent.exe
O4 - Global Startup: Microsoft Office.lnk = C:\Program Files\Office\Office10\OSA.EXE
O4 - Global Startup: WinZip Quick Pick.lnk = C:\Program Files\WinZip\WZQKPICK.EXE
O8 - Extra context menu item: &eBay Search - res://C:\Program Files\eBay\eBay Toolbar2\eBayTb.dll/RCSearch.html
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\j2re1.4.2_03\bin\npjpi142_03.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\j2re1.4.2_03\bin\npjpi142_03.dll
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O15 - ProtocolDefaults: '@ivt' protocol is in My Computer Zone, should be Intranet Zone
O15 - ProtocolDefaults: 'file' protocol is in My Computer Zone, should be Internet Zone
O15 - ProtocolDefaults: 'ftp' protocol is in My Computer Zone, should be Internet Zone
O15 - ProtocolDefaults: 'http' protocol is in My Computer Zone, should be Internet Zone
O15 - ProtocolDefaults: 'https' protocol is in My Computer Zone, should be Internet Zone
O16 - DPF: {15B782AF-55D8-11D1-B477-006097098764} (Macromedia Authorware Web Player Control) - http://www.electricp...yer/awswaxf.cab
O16 - DPF: {B38870E4-7ECB-40DA-8C6A-595F0A5519FF} (MsnMessengerSetupDownloadControl Class) - http://messenger.msn...pdownloader.cab
O16 - DPF: {D7A7442D-85A9-475F-82F9-65ED4110B4C5} - http://gpstool.globa...v30/gpstool.cab
O16 - DPF: {DAB941D8-BC94-4819-AB4D-5598C65FA3FE} - http://tb.searchitqu...com/v30/siq.cab
O23 - Service: Ati HotKey Poller - Unknown owner - C:\WINDOWS\system32\Ati2evxx.exe
O23 - Service: McAfee.com McShield (McShield) - Unknown owner - c:\PROGRA~1\mcafee.com\vso\mcshield.exe
O23 - Service: McAfee SecurityCenter Update Manager (mcupdmgr.exe) - McAfee, Inc - C:\PROGRA~1\McAfee.com\Agent\mcupdmgr.exe
O23 - Service: McAfee.com VirusScan Online Realtime Engine (MCVSRte) - McAfee, Inc - c:\PROGRA~1\mcafee.com\vso\mcvsrte.exe
O23 - Service: McAfee SpamKiller Server (MskService) - McAfee Inc. - C:\PROGRA~1\McAfee\SPAMKI~1\MSKSrvr.exe
O23 - Service: SmartLinkService (SLService) - - C:\WINDOWS\SYSTEM32\slserv.exe


By the way, any answers in easy speak would be helpful, as I am relatively new to computers and don't have all the lingo that you guys do.
Many thanks
Txacoli (Chac!)
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