Oh, Win2K, SP4, he's got an IBM Thinkpad T40, and it happens with both the laptops own keyboard and the keyboard hooked to the docking station at the desk, so it's not a keyboard issue. We can't bring up Task Manager with Ctrl Shift Esc, either, but typing taskmgr into Run fires it right up. We're going to hit the machine with Spysweeper tomorrow, but he is running Zone Alarm Pro and as it's a company machine he doesn't clickity-click and download things.
I always get these kinds of cases - I must be a weird magnet.
DB