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Cannot find application error message

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Just updated from vista 64 to windows 7 64. After update I was unable to open programs in both my daughters' user profiles. For example, when I tried to open itunes from the desktop icon or the program menu, it gave this message: C:\Program Files (x86)\itunes\itunes.exe Cannot find application. My daughters informed me that this had been happening previous to the upgrade and that to get to the programs, they had to go to the itunes.exe file and open it from there. I have run Norton av scans and still the same. I have also run malwarebytes scans. There are three other user profiles on this computer, but none are affected but theirs. They are the main users on this computer (90% of its use.) I have seen similar posts on different forums but have seen no solutions or even possible causes. Please help.
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    Kraków my love :)

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Your desktop shortcut is possibly corrupted.
Create new one.
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