I am new here, and not all that "tech-savy" so I'm hoping someone can help me

We have a computer in the office where IE will work just fine in the morning. Once you close the IE window, and then try to go to it again later, nothing loads. Doesn't even give me a "page cannot be displayed" message or anything. Just a blank page. We reboot the computer and it works just fine.
Anyone have any ideas on how I can trouble shoot and fix this problem?
Thanks so much!