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Can't Start Task Manager/No Icons on Desktop Windows XP

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I've been having issues with my computer, I was running Windows XP before the Desktop went blank (No Icons) and task manager stopped working/ can't start it any which way. Also there are pop-ups when doing searches with google and computer is really slow. Computer came with a Vista Buisness upgrade and recently upgraded to it thinking it may fix the issues. Still no Task manager or icons on desktop, but popups stopped and computer seems slightly faster. Deffinitely believe this is spyware/malware related but I can't seem to clean it. This computer is used as a POS for our business so I've put off cleaning it but want to get it working properly again. Can someone help me out if a simple spyware cleaner will do the trick or guide me through how to clean it. Any and all help is appreciated. THANK YOU!

***I'm now running Windows Vista Buisness and I have Norton internet security running on it after this issue started happening.

--Attaching OTL Scan .txt

Attached Files

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Okay so I downloaded "Malwarebytes" because it was a recommended spyware scaning tool, and it found some infections, but I want to know if I should go ahead and delete/quarentine the files/ is it safe to do so without any other complications.

I'm attaching the log for it.

Malwarebytes' Anti-Malware

Database version: 8253

Windows 6.0.6001 Service Pack 1
Internet Explorer 7.0.6001.18000

11/27/2011 5:04:36 PM
mbam-log-2011-11-27 (17-04-04).txt

Scan type: Full scan (C:\|)
Objects scanned: 268540
Time elapsed: 1 hour(s), 16 minute(s), 0 second(s)

Memory Processes Infected: 0
Memory Modules Infected: 0
Registry Keys Infected: 0
Registry Values Infected: 0
Registry Data Items Infected: 4
Folders Infected: 0
Files Infected: 1

Memory Processes Infected:
(No malicious items detected)

Memory Modules Infected:
(No malicious items detected)

Registry Keys Infected:
(No malicious items detected)

Registry Values Infected:
(No malicious items detected)

Registry Data Items Infected:
HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\ActiveDesktop\NoChangingWallPaper (PUM.Hijack.DisplayProperties) -> Bad: (1) Good: (0) -> No action taken.
HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\Explorer\NoDesktop (PUM.Hidden.Desktop) -> Bad: (1) Good: (0) -> No action taken.
HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\System\DisableTaskMgr (PUM.Hijack.TaskManager) -> Bad: (1) Good: (0) -> No action taken.
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\System\DisableTaskMgr (PUM.Hijack.TaskManager) -> Bad: (1) Good: (0) -> No action taken.

Folders Infected:
(No malicious items detected)

Files Infected:
c:\Users\kaushik patel\AppData\Local\microsoft\Windows\temporary internet files\Content.IE5\CUVNUI8J\OTM[1].exe (Trojan.Dropper.PGen) -> No action taken.
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