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Windows 7 Vista " c:\ is not accessible Access is denied."

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I've been trying to solve this problem for weeks now and to no avail so I thought I'd try you guys and see if you can help me.

I have a notebook an Acer travelmate TM8372TG-5454G50Mnbb
Windows 7/Vista

When I try and access the C drive, it says " c:\ is not accessible Access is denied."

When I try and open some other things like CCleaner and MalwareBytes, it says "Windows cannot access C:\program files......Check the spelling or there might be a problem with your network....."

I have managed to run MalwareBytes (nothing found) & Windows Reg Repair from a USB in safe mode, it didnt work. I have also run a full scan with Avast (Now Avast doesnt work and is always in unprotected mode)

I also noticed in safe mode there is a "repair your computer" option, I tried that and no success either.

I have been able to system restore in safe mode but that didnt work either. ( I couldnt restore in normal admin mode, it wouldnt let me)

I can access the internet ok but cant seem to open anything that needs to run, picture and movie folders are all accessible (but not via the c: drive)

If anyone can help or has a solution I'd be really grateful.

Thank you
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