I have a reasonable amount of experience at dealing with this kind of problem and have usually managed to sort it out on my own but this one has defeated me so your help would be greatly appreciated.
I have run SpyBot, Adaware, SAS, AVG and MBAM. They all found stuff and removed it, and are all reporting no infection now. Housecall crashes the system completely while loading and ComboFix crashes the system before it can even complete the very 1st progress bar. I went to your Malware Cleaning Guide page and have done everything there, and am about to attach those logs. I had one serious problem which was that GMER crashes when it reaches the very first file of the scan, at least 10 or 15 mins into the scan. It crashes at iaStor.sys and the comment is 'suspicious modification'. This crash has now happened 3 times at exactly the same moment, so I have to do a hard reboot. So I have no log from GMER, but I could set it to do a scan and uncheck Files on the right hand menu to try to stop it getting to that point if it would help. You could then at least see what the scan found up to that point.
I looked up iaStor.sys and it seems to be something to do with Intel drivers but this PC has been working fine for years, and there is certainly something infecting it. The browser hijacks are happening randomly, usually after clicking on a Google search link, and taking me to a host of different sites, none of which seem that dodgy (smartbizsearch is a regular treat) and similar. Taking ages to load a webpage is common, as are full system crashes. Lost count of the number of hard reboots I've done in the past few days.
That's as much info as I can think of for now. Here are the 3 logs from OTL and MBAM.
Many thanks for your help.
Helen OTL.Txt 129.9KB 226 downloads mbam_log_2009_12_18__23_16_08_.txt 868bytes 194 downloads Extras.Txt 60.88KB 381 downloads