When installing it there should be and option of choseing where to install it, and you can chose the Portable drive, if there it not this option you can't install it any where but C drive. I have never installed it so don't know if there is this option. you must rember that becides install in it to it ?:/program files ? programs insert files in to other parts of you somputer such a C:/windows and also in to the regestry so evan if you install it in to the Portable drive it might not work on other computers and might not work on the one you used to install it if the drive letter that repersents the portable drive changes.