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open with box comes up every time i try to execute a program

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I have a very strange situation. I am running XP Home with SP2. I know it is infected with a virus or spyware, but I cannot get any of my "killer" apps to install. In fact, no programs will run at all. Every time I try to install anti-virus or anti-spyware programs, or run any existing programs, the "Open With" box pops up and the software won't load. Please don't tell me to go to a website and download something on my computer, because IE also has this problem
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