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My IE has been Hijacked

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Hi My IE has been HiJacked by some ad-ware and I can't get rid of it Here is my Hijack this log.

Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 4:16:56 PM, on 6/20/2008
Platform: Windows Vista (WinNT 6.00.1904)
MSIE: Internet Explorer v7.00 (7.00.6000.16681)
Boot mode: Normal

Running processes:
C:\Program Files\Google\Google Desktop Search\GoogleDesktop.exe
C:\Program Files\Spare Backup\SpareBackup.exe
C:\Program Files\BigFix\bigfix.exe
C:\Program Files\SiteAdvisor\6261\SiteAdv.exe
C:\Program Files\Windows Media Player\wmpnscfg.exe
C:\Program Files\Hewlett-Packard\Digital Imaging\bin\hpohmr08.exe
C:\Program Files\Google\Google Desktop Search\GoogleDesktopIndex.exe
C:\Program Files\Google\Google Desktop Search\GoogleDesktopCrawl.exe
C:\Program Files\Mozilla Firefox\firefox.exe
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft....k/?LinkId=54896
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.gmail.com/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://www.gateway.c...h...DTP&M=W3629
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft....k/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft....k/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.gateway.c...h...DTP&M=W3629
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant = http://www.gateway.c...h...DTP&M=W3629
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch =
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
O1 - Hosts: ::1 localhost
O2 - BHO: (no name) - {02478D38-C3F9-4efb-9B51-7695ECA05670} - (no file)
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Common Files\Adobe\Acrobat\ActiveX\AcroIEHelper.dll
O2 - BHO: (no name) - {089FD14D-132B-48FC-8861-0048AE113215} - C:\Program Files\SiteAdvisor\6261\SiteAdv.dll
O2 - BHO: IE ext - {2FF811E6-8925-4084-A649-C159955E67E8} - C:\Windows\system32\ipol.dll
O2 - BHO: McAntiPhishingBHO - {377C180E-6F0E-4D4C-980F-F45BD3D40CF4} - c:\PROGRA~1\mcafee\msk\mcapbho.dll
O2 - BHO: SSVHelper Class - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre1.6.0_01\bin\ssv.dll
O2 - BHO: scriptproxy - {7DB2D5A0-7241-4E79-B68D-6309F01C5231} - C:\Program Files\McAfee\VirusScan\scriptsn.dll
O2 - BHO: Google Toolbar Helper - {AA58ED58-01DD-4d91-8333-CF10577473F7} - c:\program files\google\googletoolbar1.dll
O2 - BHO: Browser Address Error Redirector - {CA6319C0-31B7-401E-A518-A07C3DB8F777} - c:\windows\system32\BAE.dll
O3 - Toolbar: &Google - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - c:\program files\google\googletoolbar1.dll
O3 - Toolbar: McAfee SiteAdvisor - {0BF43445-2F28-4351-9252-17FE6E806AA0} - C:\Program Files\SiteAdvisor\6261\SiteAdv.dll
O4 - HKLM\..\Run: [Windows Defender] %ProgramFiles%\Windows Defender\MSASCui.exe -hide
O4 - HKLM\..\Run: [IgfxTray] C:\Windows\system32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\Windows\system32\hkcmd.exe
O4 - HKLM\..\Run: [Persistence] C:\Windows\system32\igfxpers.exe
O4 - HKLM\..\Run: [RtHDVCpl] RtHDVCpl.exe
O4 - HKLM\..\Run: [Google Desktop Search] "C:\Program Files\Google\Google Desktop Search\GoogleDesktop.exe" /startup
O4 - HKLM\..\Run: [Spare Backup] "C:\Program Files\Spare Backup\SpareBackup.exe" /silent
O4 - HKLM\..\Run: [BigFix] c:\program files\Bigfix\bigfix.exe /atstartup
O4 - HKLM\..\Run: [SiteAdvisor] "C:\Program Files\SiteAdvisor\6261\SiteAdv.exe"
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\qttask.exe" -atboottime
O4 - HKLM\..\Run: [mcagent_exe] C:\Program Files\McAfee.com\Agent\mcagent.exe /runkey
O4 - HKLM\..\RunOnce: [Launcher] %WINDIR%\SMINST\launcher.exe
O4 - HKCU\..\Run: [Uniblue RegistryBooster 2] c:\program files\uniblue\registrybooster 2\StartRegistryBooster.exe
O4 - HKCU\..\Run: [AdobeUpdater] C:\Program Files\Common Files\Adobe\Updater5\AdobeUpdater.exe
O4 - HKCU\..\Run: [WMPNSCFG] C:\Program Files\Windows Media Player\WMPNSCFG.exe
O4 - HKUS\S-1-5-19\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-19\..\Run: [WindowsWelcomeCenter] rundll32.exe oobefldr.dll,ShowWelcomeCenter (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-20\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User 'NETWORK SERVICE')
O4 - HKUS\S-1-5-18\..\Run: [MySpaceIM] C:\Program Files\MySpace\IM\MySpaceIM.exe (User 'SYSTEM')
O4 - HKUS\.DEFAULT\..\Run: [MySpaceIM] C:\Program Files\MySpace\IM\MySpaceIM.exe (User 'Default user')
O4 - Global Startup: BigFix.lnk = C:\Program Files\BigFix\bigfix.exe
O4 - Global Startup: hp psc 1000 series.lnk = ?
O4 - Global Startup: hpoddt01.exe.lnk = ?
O8 - Extra context menu item: &ieSpell Options - res://C:\Program Files\ieSpell\iespell.dll/SPELLOPTION.HTM
O8 - Extra context menu item: Check &Spelling - res://C:\Program Files\ieSpell\iespell.dll/SPELLCHECK.HTM
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\Office12\EXCEL.EXE/3000
O8 - Extra context menu item: Lookup on Merriam Webster - file://C:\Program Files\ieSpell\Merriam Webster.HTM
O8 - Extra context menu item: Lookup on Wikipedia - file://C:\Program Files\ieSpell\wikipedia.HTM
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0_01\bin\npjpi160_01.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0_01\bin\npjpi160_01.dll
O9 - Extra button: ieSpell - {0E17D5B7-9F5D-4fee-9DF6-CA6EE38B68A8} - C:\Program Files\ieSpell\iespell.dll
O9 - Extra 'Tools' menuitem: ieSpell - {0E17D5B7-9F5D-4fee-9DF6-CA6EE38B68A8} - C:\Program Files\ieSpell\iespell.dll
O9 - Extra button: (no name) - {1606D6F9-9D3B-4aea-A025-ED5B2FD488E7} - C:\Program Files\ieSpell\iespell.dll
O9 - Extra 'Tools' menuitem: ieSpell Options - {1606D6F9-9D3B-4aea-A025-ED5B2FD488E7} - C:\Program Files\ieSpell\iespell.dll
O9 - Extra button: Send to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~2\Office12\ONBttnIE.dll
O9 - Extra 'Tools' menuitem: S&end to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~2\Office12\ONBttnIE.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\Office12\REFIEBAR.DLL
O13 - Gopher Prefix:
O16 - DPF: {02BF25D5-8C17-4B23-BC80-D3488ABDDC6B} (QuickTime Object) - http://appldnld.appl...ex/qtplugin.cab
O16 - DPF: {48DD0448-9209-4F81-9F6D-D83562940134} (MySpace Uploader Control) - http://lads.myspace....ploader1006.cab
O20 - AppInit_DLLs: C:\PROGRA~1\Google\GOOGLE~1\GOEC62~1.DLL
O23 - Service: Lavasoft Ad-Aware Service (aawservice) - Lavasoft - C:\Program Files\Lavasoft\Ad-Aware\aawservice.exe
O23 - Service: Agere Modem Call Progress Audio (AgereModemAudio) - Agere Systems - C:\Windows\system32\agrsmsvc.exe
O23 - Service: GoogleDesktopManager - Google - C:\Program Files\Google\Google Desktop Search\GoogleDesktopManager.exe
O23 - Service: Google Updater Service (gusvc) - Google - C:\Program Files\Google\Common\Google Updater\GoogleUpdaterService.exe
O23 - Service: McAfee Services (mcmscsvc) - McAfee, Inc. - C:\PROGRA~1\McAfee\MSC\mcmscsvc.exe
O23 - Service: McAfee Network Agent (McNASvc) - McAfee, Inc. - c:\program files\common files\mcafee\mna\mcnasvc.exe
O23 - Service: McAfee Scanner (McODS) - McAfee, Inc. - C:\PROGRA~1\McAfee\VIRUSS~1\mcods.exe
O23 - Service: McAfee Proxy Service (McProxy) - McAfee, Inc. - c:\PROGRA~1\COMMON~1\mcafee\mcproxy\mcproxy.exe
O23 - Service: McAfee Real-time Scanner (McShield) - McAfee, Inc. - C:\PROGRA~1\McAfee\VIRUSS~1\mcshield.exe
O23 - Service: McAfee SystemGuards (McSysmon) - McAfee, Inc. - C:\PROGRA~1\McAfee\VIRUSS~1\mcsysmon.exe
O23 - Service: McAfee Personal Firewall Service (MpfService) - McAfee, Inc. - C:\Program Files\McAfee\MPF\MPFSrv.exe
O23 - Service: McAfee SpamKiller Service (MSK80Service) - McAfee, Inc. - C:\Program Files\McAfee\MSK\MskSrver.exe
O23 - Service: SiteAdvisor Service - Unknown owner - C:\Program Files\SiteAdvisor\6261\SAService.exe

End of file - 8947 bytes

Thanks for any help you can give
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