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When starting up my computer Spybot finds that ISDELETEME has changed in the registry. It says its in teh cmd or system file. After researching, it said to run a registry cleaner. I did. Still comes up. What is it? Should I allow teh change at start up?
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isdelete is part of Norton internet security.
Did you have Norton and then uninstall it?
If so, then try Norton removal tool found HERE

You could also post in the malware removal forum and have the log checked for malware. There is a registry key associated with it and the malware techs can help delete it.

Name: isDeleteMe
Command: isDel.bat
Status: User's choice. Start if necessary.
Description: Used by Norton Internet Security to remove certain files and directories on reboot when uninstalling their product

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