Sometimes they have files in them, sometimes they are empty.
Here are 2 examples
C:\Documents and Settings\jsmith\Local Settings\Application Data\{30D0017D-D816-49E6-9A5E-437E3C2C22A7}
C:\Documents and Settings\jsmith\Local Settings\Application Data\{7148F0A6-6813-11D6-A77B-00B0D0142070}
In one of these for example, there are 2 files
1033.mst - MST file
java2 runtime enviroment - Windows Installer Package
Is there any general rule about if directories like these can be deleted without problems? or should they always be left?