Will i see big difference???
Depends on the task but generally, with the better CPU and 8Gb of RAM, the general improvement should be significant.
However, a couple things. You may need a bigger PSU.
Also the motherboard is the heart and soul of a computer and as such, in terms of software licensing, a new motherboard constitutes a new computer. OEM software is tied to the "original equipment". Therefore, any OEM software that came with, or was purchased for the "old" computer/motherboard is tied to that old equipment. So, if your current Windows license is an OEM license that came with your old computer/motherboard, you MUST buy a new Windows license to be legal.
That said, since you are upgrading from 4Gb of RAM to 8Gb of RAM, to take advantage of the 8Gb of RAM, you need to use a 64-bit operating system. So if your current OS for your 4Gb system is 32-bit, you need to buy a new OS anyway.
Finally, on the ASUS motherboard's webpage, you should see two lists for compatible CPUs and RAM. Check those lists to ensure your CPU is listed. There are too many RAM makers and models for ASUS to test them all, so you can buy off the list. Just make sure the RAM you select has the same electrical specs as listed RAM.