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Cant open any file

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I have something on my computer that wont let me open any of my files, i managed to open spy sweeper and spy doctor and i ran them and deleted w.e showed up but it still doesn;t let me run files, my homepage keeps on changing and i cant open regedit. i also cant download anything because it wont let me open it. please respond asap thankz
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I know you can't download anything onto your computer. But I need you to download Hijack This. Follow these insturctions.

"Let us take a closer look at what is running on your PC. We'll need you to use a free diagnostic tool (HiJackThis) and post a log as a new topic in the Hijack This forum. It will get a better response there from the people most qualified to analyze logs.

Click the HijackThis Guide in my signature, download it and follow the instructions in the guide. Also see this post.

Most of what it lists will be harmless or even essential, DO NOT delete or modify anything yet! Someone will be along to tell you what steps to take after you post the contents of the scan results."

Download it following these instructions.

Extract the zip file to C:/hjt for example then go to the folder right click on Hijackthis and rename it (don't use the word Hijack when renaming the file). Then try to open it.

If that does not work download and run SMARTKILLER tool: »www.safer-networking.org/files/delcwss..

This tool is a "Might Help, CAN'T HURT" type so dont worry if it doesnt fix the issue

The following post describes a similar problem.
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