Run Killbox (doubleclick Killbox.exe).
Run it, and click the radio button that says Delete a file on reboot. For the file in the box below, paste it into the full path of file to delete box and click the red circle with a white cross in it.
The program will ask you if you want to reboot; say Yes.
Let the system reboot.
C:\Program Files\MouseWare\system\A0022285.exe