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Help please! I cannot open any of my programs

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I cannot open any of my programs, when I try I get this message "This file does not have a program associated with it for performing this action. Create an association in the Set Associations control panel." I dont know what has caused this. I have done a virus check with AVG and nothing was found. I have done a system restore, but it has not made any difference.

I would really appreciate it if anyone has any ideas or information that could possibly help me fix this.

Thanking you.

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What was the last application/program you downloaded? Also what version of Vista are you running?

The more information you can give, the more we can help 'trouble shoot' your problem.
Clean install?
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