First of all I want to say I am very thankful for all your help, and I do apologise if my last post seemed a little sarcastic or moody! (Put it down to frustration of not finding the root of the problem and a moody partner!)
Anyway,
Having more than one AV installed on your computer can cause conflicts. I recommend removing AVG.
I know of course I didn’t install them all simultaneously!! All uninstall / install (I made the mistake of doing something like that when I first began to use computers (aged about 12!) thinking it would be more secure and then wondered why my system was lagging and giving me all types of errors!)
I can't find any info on Spycop, and I'm not familiar with it. Spywaredetector used to be rogue, it would find false positives. If this is a newer version, then it is okay. See Spyware warrior's rogue anti-spyware list for more info.
I did actually download Spycop some time ago and may be some what outdated (I don’t remember or couldn’t? update the definitions either), Spywaredetector was a freshly downloaded copy from their site. I also did another check with "Webroot Spy Sweeper 4.5" http://www.webroot.com, because you have me very paranoid now! But thankfully no infections
But as for isafe.exe, it was NOT installed on my computer when I installed ZoneAlarm. In fact, you said that isafe.exe is part of eTrust Antivirus. And yet it is in a ZoneLabs folder in System32! You did not say that you had eTrust, so I remain suspicious about this file.
I understand your concerns completely because isafe.exe is apparently not installed with the basic Zonealarm firewall. Now remember Zonelabs is a company that specialises (or at least did originally) in specifically firewalls.
Zonelabs uses Antivirus components manufactured by Computer Associates who also happen to manufacture that component for eTrust AV (explaining why their name is being used in the description of the file) even though, this still seemed a little strange to me. It is not much harder to re-brand it do Zone Alarm AV. So I have sent a copy of the file to Zonelabs to confirm its authenticity, I will post and inform you of the results when / if I hear back. A quick search of their forums will inform you of the link between isafe.exe and ZA: here and here
Once again I thank you greatly for all your help, and will make a post in the networking forum to see if they can get to the bottom of this! I will post the link here when I have done it so you can follow its progress.
Thanks again it has been a pleasure talking to you. Good luck with the training, I am sure you will be promoted to staff in no time at all!
All the best